Panosteitis is characterized by an increase in activity of osteoblasts and fibroblasts in the periosteum, endosteum and bone marrow. This results in fibrosis and the formation of connective tissue in the medullary cavity of the affected bone. Pain may be caused by increased pressure in the medullary cavity and the stimulation of pain receptors in the periosteum.
Panosteitis usually affects the long bones in the legs of young dogs and is more common in medium- to large-sized dog breeds.
The inflammation can affect one or more of the dog's limbs resulting in extreme pain during movement. Once the inflammation is reduced, full function and activity is restored.
Fever, depression, weight loss, and anorexia can also be observed at times. If not treated timely, it may also result in loss of muscle mass over time due to lack of muscle usage.
