Bone Marrow Cancer, Myeloma in Dogs

Multiple myeloma is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. In this condition, abnormal plasma cells accumulate in the bone marrow and interfere with the production of normal blood cells. Production of Paraprotein (an abnormal antibody causing kidney problems) is also seen in most cases along with bone lesions and hypercalcemia.

Multiple myeloma is attributed to bone infiltration and destruction of the bone and infiltration of organ(s) by cancerous cells. Symptoms depend on the location and extent of the disease. Common symptoms include  

Weakness, lethargy


Bone pain and weakness with destruction of areas of bone


Partial paralysis

Dementia with generalized discomfort or uneasiness Labored breathing

Pale gums and mucous membranes

Increased thirst and increased urination with increased levels of calcium in the blood or kidney dysfunction

Urinary incontinence

Enlarged liver and spleen

Excessive bleeding

Bleeding in the gastrointestinal tract

Bleeding from the nose or mucous membranes

Retinal Hemorrhage and blindness

Detached retina




Leave a Comment