The liver is the primary site of synthesis of coagulation, anticoagulant, and fibrinolytic proteins. In fact, only five blood clotting factors are not produced there. Therefore, liver diseases that cause clotting issues in dogs can be very serious and sometimes life-threatening.
Symptoms indicative of liver related coagulopathies include
Black feces due to digested blood (melena)
Bright red blood in the feces (hematochezia)
Vomiting or spitting up blood (hematemesis)
Prolonged bleeding after trauma