Phosphofructokinase Deficiency in Dogs

Canine Phosphofructokinase (PFK) deficiency is an autosomal recessive genetic disease which prevents the metabolism of glucose into available energy resulting in exercise intolerance and muscle disease.  PFK deficiency also destroys red blood cells in affected dogs, leading to anemia.

This condition, when occurs, inhibits the body from metabolizing glucose into useable energy, leading to weakness and exercise intolerance. In advance stages, the condition can lead to more advance muscular diseases and destruction of red blood cells, causing anemia.

This metabolic disorder has a genetic basis, affecting certain breeds such as English Springer Spaniels, American Cocker Spaniels, and mixed breed dogs.

Symptoms associated with this disorder depend on severity of the condition. Common symptoms include:



Lethargy or general weakness

Blood in urine (hematuria)

Pale mucous membranes

Muscle wasting and cramping

Exercise intolerance


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